2. Metabolic Disease

Metabolic Disease

Metabolic Disease

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Metabolic diseases is defined by a constellation of interconnected physiological, biochemical, clinical, and metabolic factors that directly increases the risk of cardiovascular disease, type 2 diabetes mellitus, and all cause mortality. Associated conditions include hyperuricemia, fatty liver (especially in concurrent obesity) progressing to nonalcoholic fatty liver disease, polycystic ovarian syndrome (in women), erectile dysfunction (in men), and acanthosis nigricans. Metabolic disease modeling is an essential component of biomedical research and a mandatory prerequisite for the treatment of human disease. Somatic genome editing using CRISPR/Cas9 might be used to establish novel metabolic disease models.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-P2890C
    Laccase, Rhus vernicifera
    Laccase, Trametes versicolor (EC 1.10.3.2), is a blue copper oxidase that reduces molecular oxygen to water. Laccase can oxidize polyphenols, methoxylated phenolic compounds, and diamines, but not tyrosine. Laccase's oxidation reaction is a single-electron reaction and produces free radicals.
    Laccase, Rhus vernicifera
  • HY-P2890D
    Laccase, Agaricus bisporus
    Laccase, Agaricus bisporus (EC 1.10.3.2) is a blue copper oxidase that reduces molecular oxygen to water. Laccase oxidizes polyphenols, methoxy-substituted phenols and diamines, but not tyrosine. Oxidation by laccase is an one-electron reaction that generates a free radical.
    Laccase, Agaricus bisporus
  • HY-P2890E
    Laccase, Coriolus versicolor
    Laccase, Coriolus versicolor is a copper-containing oxidase enzyme that are found in many plants, fungi, and microorganisms. The copper is bound in several sites; Type 1, Type 2, and/or Type 3. The ensemble of types 2 and 3 copper is called a trinuclear cluster. Type 1 copper is available to action of solvents, such as water.
    Laccase, Coriolus versicolor
  • HY-P2890H
    Laccase, Pleurotus ostreatus (mushroom)
    Laccase, Pleurotus ostreatus (mushroom) (EC 1.10.3.2) is a blue copper oxidase that reduces molecular oxygen to water. Laccase oxidizes polyphenols, methoxy-substituted phenols and diamines, but not tyrosine. Oxidation by laccase is an one-electron reaction that generates a free radical.
    Laccase, Pleurotus ostreatus (mushroom)
  • HY-P2890I
    Laccase, White rot fungi
    Laccase, White rot fungi (EC 1.10.3.2) is a blue copper oxidase that reduces molecular oxygen to water. Laccase oxidizes polyphenols, methoxy-substituted phenols and diamines, but not tyrosine. Oxidation by laccase is an one-electron reaction that generates a free radical.
    Laccase, White rot fungi
  • HY-P2893C
    Creatinase, Flavobacterium sp.
    Creatinase, Flavobacterium sp. (EC 3.5.3.3) belongs to the hydrolase family and acts on carbon-nitrogen bonds other than peptide bonds, especially in linear amidine compounds. Creatinase, Flavobacterium sp. (EC 3.5.3.3) accelerates the conversion of creatine and water molecules into sarcosine and urea. Creatinase, Flavobacterium sp. (EC 3.5.3.3) functions as a homodimer.
    Creatinase, Flavobacterium sp.
  • HY-P2897A
    D-Lactic Dehydrogenase, Staphylococcus epidermidis
    D-Lactic Dehydrogenase, Staphylococcus epidermidis (EC 1.1.1.28) catalyzes the conversion of D-lactate into D-pyruvate while reducing NAD+ to NADH and H+.
    D-Lactic Dehydrogenase, Staphylococcus epidermidis
  • HY-P2897B
    D-Lactic Dehydrogenase, Lactobacillus leichmanii
    D-Lactic Dehydrogenase, Lactobacillus leichmanii (EC 1.1.1.28) catalyzes the conversion of D-lactate into D-pyruvate while reducing NAD+ to NADH and H+.
    D-Lactic Dehydrogenase, Lactobacillus leichmanii
  • HY-P2897C
    D-Lactic Dehydrogenase, Leuconostoc mesenteroides
    D-Lactic Dehydrogenase, Leuconostoc mesenteroides (EC 1.1.1.28) is an oxidoreductase that acts on the CH-OH group in the donor molecule and uses cytochrome as the acceptor. D-Lactic Dehydrogenase, Leuconostoc mesenteroides (EC 1.1.1.28) is involved in pyruvate metabolism. It uses a cofactor, namely FAD.
    D-Lactic Dehydrogenase, Leuconostoc mesenteroides
  • HY-P2901A
    3α-Hydroxysteroid Dehydrogenase, Pseudomonas testosteroni
    3α-Hydroxysteroid Dehydrogenase, Pseudomonas testosteroni (EC 1.1.1.50) belongs to the oxidoreductase family. Its three substrates are androstenedione, NAD+, and NADP+, while its four products are 5α-androstane-3,17-dione, NADH, NADPH, and H+. 3α-Hydroxysteroid Dehydrogenase, Pseudomonas testosteroni, acts on the CH-OH group of the donor molecule, with NAD+ or NADP+ as the acceptor.
    3α-Hydroxysteroid Dehydrogenase, Pseudomonas testosteroni
  • HY-P2912A
    Glutamate Dehydrogenase (NADP-dependent), Proteus sp.
    Glutamate Dehydrogenase (NADP-dependent), Proteus sp. (EC 1.4.1.4), is an enzyme found in the mitochondria of most microorganisms and eukaryotes that converts glutamate to α-ketoglutarate.
    Glutamate Dehydrogenase (NADP-dependent), Proteus sp.
  • HY-P2917B
    Glycerol kinase, Flavobacterium meningosepticum 9030-66-4 98%
    Glycerol kinase, Flavobacterium meningosepticum (GyK, Flavobacterium meningosepticum) is a thermostable glycerol kinase isolated from Flavobacterium meningosepticum. Glycerol kinase, Flavobacterium meningosepticum catalyzes the first step in glycerol metabolism by converting triol to glycerol-3-p (G3P). Glycerol kinase, Flavobacterium meningosepticum is essential for regulating glycerol uptake in cells that is independent of channels or facilitators and is useful for biochemical studies.
    Glycerol kinase, Flavobacterium meningosepticum
  • HY-P2918A
    Phosphoglucose isomerase, bacillus stearothermophilus 9001-41-6 98%
    Phosphoglucose isomerase, bacillus stearothermophilus is a highly conserved glycolytic and dimeric enzyme. Phosphoglucose isomerase, bacillus stearothermophilus catalyzes the reversible isomerization of glucose-6-phosphate to fructose-6-phosphate.
    Phosphoglucose isomerase, bacillus stearothermophilus
  • HY-P2918B
    Phosphoglucose isomerase, Baker's Yeast 9001-41-6 98%
    Phosphoglucose isomerase, bacillus stearothermophilus is a highly conserved glycolytic and dimeric enzyme. Phosphoglucose isomerase, bacillus stearothermophilus catalyzes the reversible isomerization of glucose-6-phosphate to fructose-6-phosphate.
    Phosphoglucose isomerase, Baker's Yeast
  • HY-P2918C
    Phosphoglucose isomerase, Saccharomyces cerevisiae
    Phosphoglucose isomerase, Saccharomyces cerevisiae (EC 5.3.1.9) is an enzyme crucial for the interconversion of D-glucose 6-phosphate and D-fructose 6-phosphate. Phosphoglucose isomerase is responsible for the second step of glycolysis and is involved in glucogenesis.
    Phosphoglucose isomerase, Saccharomyces cerevisiae
  • HY-P2918D
    Phosphoglucose isomerase, E.coli
    Phosphoglucose isomerase, E.coli (EC 5.3.1.9) is an enzyme crucial for the interconversion of D-glucose 6-phosphate and D-fructose 6-phosphate. Phosphoglucose isomerase is responsible for the second step of glycolysis and is involved in glucogenesis.
    Phosphoglucose isomerase, E.coli
  • HY-P2918E
    Phosphoglucose isomerase, Bacillus subtilis
    Phosphoglucose isomerase, Bacillus subtilis (EC 5.3.1.9) is an enzyme crucial for the interconversion of D-glucose 6-phosphate and D-fructose 6-phosphate. Phosphoglucose isomerase is responsible for the second step of glycolysis and is involved in glucogenesis.
    Phosphoglucose isomerase, Bacillus subtilis
  • HY-P2921A
    Uricase, Bacillus fastidious 9002-12-4 98%
    Uricase, Bacillus fastidious (Uox, Bacillus fastidious) is a uricase (urate oxidase) derived from Bacillus fastidious. Uricase, Bacillus fastidious converts uric acid into allantoin. The absence of Uricase in mammals causes kidney diseases resulting from uric acid accumulation. Uricase, Bacillus fastidious can be used for research on chronic refractory gout and hyperuricemia.
    Uricase, Bacillus fastidious
  • HY-P2921B
    Uricase, Arthrobacter globiformis 9002-12-4 98%
    Uricase, Arthrobacter globiformis (Uox, Arthrobacter globiformis) is a uricase (urate oxidase) derived from Arthrobacter globiformis. Uricase, Arthrobacter globiformis converts uric acid into allantoin. The absence of Uricase in mammals causes kidney diseases resulting from uric acid accumulation. Uricase, Arthrobacter globiformis can be used for research on chronic refractory gout and hyperuricemia.
    Uricase, Arthrobacter globiformis
  • HY-P2921E
    Uricase, Candida sp. 98%
    Uricase, Candida sp. (Uox, Candida sp.) is a uricase (urate oxidase) derived from Candida sp.. Uricase, Candida sp. converts uric acid into allantoin. The absence of Uricase in mammals causes kidney diseases resulting from uric acid accumulation. Uricase, Candida sp. can be used for research on chronic refractory gout and hyperuricemia.
    Uricase, Candida sp.
Cat. No. Product Name / Synonyms Application Reactivity